منابع مشابه
Astrocyte regulation of cerebral vascular tone.
Cerebral blood flow is controlled by two crucial processes, cerebral autoregulation (CA) and neurovascular coupling (NVC) or functional hyperemia. Whereas CA ensures constant blood flow over a wide range of systemic pressures, NVC ensures rapid spatial and temporal increases in cerebral blood flow in response to neuronal activation. The focus of this review is to discuss the cellular mechanisms...
متن کاملCarbon monoxide and cerebral microvascular tone in newborn pigs.
The present study addresses the hypothesis that CO produced from endogenous heme oxygenase (HO) can dilate newborn cerebral arterioles. HO-2 protein was highly expressed in large and small blood vessels, as well as parenchyma, of newborn pig cerebrum. Topically applied CO dose-dependently dilated piglet pial arterioles in vivo over the range 10-11-10-9M (maximal response). CO-induced cerebrovas...
متن کاملHydrogen sulfide and cerebral microvascular tone in newborn pigs.
Hydrogen sulfide (H2S) is a gaseous signaling molecule that appears to be involved in numerous biological processes, including regulation of blood pressure and vascular tone. The present study is designed to address the hypothesis that H2S is a functionally significant, endogenous dilator in the newborn cerebrovascular circulation. In vivo experiments were conducted using newborn pigs with surg...
متن کاملRole of potassium channels in regulation of cerebral vascular tone.
Several types of potassium (K+) channels are present in cerebral blood vessels. Opening or closure of these ion channels may have significant effects on membrane po tential, which is a major determinant of entry of extra cellular calcium and thus vascular tone, Because of the ionic properties of the cell membrane at rest, the change in activity of only a few K+ channels is sufficient to chang...
متن کاملSimulated microgravity increases myogenic tone in rat cerebral arteries.
Adaptation of the cerebral circulation to microgravity was investigated in rat middle cerebral arteries after 20 days of hindlimb unweighting (HU). Myogenic responses were measured in isolated, pressurized arteries from HU and control animals. Maximal passive lumen diameters, obtained in the absence of extracellular Ca2+ plus EDTA, were not significantly different between groups (249 vs. 258 mi...
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ژورنال
عنوان ژورنال: The Journal of Nervous and Mental Disease
سال: 1918
ISSN: 0022-3018
DOI: 10.1097/00005053-191804000-00024